Swedish study: Gastric bypass affects genetic activity

 

 

 

A Swedish study concluded that the genetic activity in adipose tissue changes after surgical reduction of the stomach. And some changes remain in the long run, which may lead to maintaining the positive effects of the process in relation to metabolism, even if the weight increases again.

The researchers took from 50 women a small sample of the abdominal fat tissue before the operation, then a sample of 49 women two years after the operation, then a sample of 38 women five years after the operation (as possible after these two periods).

The researchers also examined obese women who did not undergo surgery by comparison, and it was found that women lost an average of 38 kilograms in the first two years after surgery, and then increased their weight in the following years by an average of eight kilograms.

 

 

The most prominent results of the study

 

The researchers studied how the activity of genes in adipose tissue changed over time, and most of the changes occurred in the first two years after the operation, as there was an increase or decrease in the activity of more than 5500 genes, among them many genes that are related to the immune response and inflammatory reactions.

Part of the positive changes remained until five years after the operation, and even with the overweight of the specimens again, and these changes affected the metabolism of fats and the regulation of inflammation, and the researchers said that this could explain the continued positive effects after the gastric reduction process, including For example protection from diabetes.

The researchers said that it is known, for example, that such surgery can at best lead to a cure for type 2 diabetes, and it can also prevent the recurrence of this disease even in the event of a new weight gain, according to the Swedish team of scientists headed by Steyr. CARE from the Karlonska Institute in Stockholm, Sweden.

The positive effect is attributed to, among other things, the change in hormone secretion within the intestine, and researchers expected that white fat tissue could play an important role in this.

They said that the metabolism of white fats changed in obese people, with signs of persistent mild inflammation. Researchers have studied these relationships in overweight women who have had a gastric bypass, also known more precisely as a stomach transformation (ru ny) or gastric bypass.

 

 

What is the process of stomach reduction?

 

In this process a break is made a few centimeters below the entrance to the stomach and this part is connected with the small intestine, and the remaining small stomach receives a small amount of food which leads to the generation of a sense of satiety quickly, as the digestive juices are reoriented in such a way that they mix with food late , Which leads to the absorption of less nutrients.